Figure 3.

Time course of inhibition of A. BgNav1-1a, B. BgNa_v1-1a^F1817A, or C. BgNa_v1-1^Y1824A channels by indoxacarb, DCJW, or metaflumizone in depolarized oocytes. Currents were elicited once every minute for 30 min with 20-ms test pulses to -10 mV from holding potentials of -60 mV (BgNa_v1-1a and BgNa_v1-1a^Y1824A) or -65 mV (BgNa_v1-1a^F1817A). Insecticides were applied during the first 5 min of recording and remained in the bath throughout the rest of the recording period. Currents were normalized to the first current recorded just prior to insecticide application.