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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Neurotoxicology. 2009 Apr 8;30(4):613–621. doi: 10.1016/j.neuro.2009.03.009

Table 2.

Dissociation constants, Kd and Hill coefficients, p, for binding of DCJW and metaflumizone to BgNav1-1a BgNav1-1aF1817A and BgNav1-1aY1824A sodium channels, derived from fits of the time course of recovery at -120 mV from equilibration with the SCBIs under strong depolarization (Figs. 6-8)


DCJW Metaflumizone

Kd (nM) p Kd (nM) p
BgNav1-1a 25.5 0.96 112 1.13
BgNav1-1aF1817A 33.5 0.70 - -
BgNav1-1aY1824A 1.9 0.6 10 0.47