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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: J Immunol. 2009 Jan 1;182(1):138–147. doi: 10.4049/jimmunol.182.1.138

FIGURE 7. Immature B cells in aged BALB/c and λ5 knockout bone marrow exhibit altered light chain expression in vivo.

FIGURE 7

(A) Representative histograms show κ light chain expressing immature (AA4.1+) bone marrow B cells from young and old BALB/c mice and WT (B6) and λ5 KO mice in vivo. (B) Summary of light chain expression on immature bone marrow B cells from young and aged BALB/c mice and WT (B6) and λ5 KO mice. (C) Relative incidences of light chain expression among CD43- and CD43+ immature B cells in young and aged BALB/c bone marrow. (D) Bone marrow (BM) immature B cells (sIgM+ AA4.1+ CD19+) and splenic (SP) transitional B cells (sIgM+ AA4.1+ CD19+) from λ5 KO and aged mice were further evaluated for κ and λ dual light chain expression. Aged mice were chosen that had substantial increases in dual light chain isotype expressing immature B cells in their bone marrow for comparison with those in spleen. Data are cumulative for 3-8 mice. *, p<0.05.