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. Author manuscript; available in PMC: 2010 May 25.
Published in final edited form as: Virology. 2009 Apr 5;388(1):78–90. doi: 10.1016/j.virol.2009.02.050

Figure 9. RCMV Induced Reduction In MHC I and II Expression Is Not Mediated By Viral Binding and Entry, Late Gene Expression Or By A Secreted Factor.

Figure 9

A. BMDC were infected at an MOI=1 with RCMV-Wt (thin black line) or Wt-UV inactivated (dashed black line) or mock infected (thick black line) for 48h and analyzed by FACS for cell surface expression of MHC I and II. Isotype control (grey).

B. BMDC were pretreated with Foscarnet or mock, and then infected at an MOI equal to one with RCMV-Wt. Isotype control (grey), Uninfected + Foscarnet (thick black line), Infected + Foscavir (thin black line), Infected − Foscarnet (dashed black line).

C. BMDC were infected with RCMV-Wt (thin black line) or mock (thick black line), or conditioned supernatants from RCMV infected BMDCs (dashed black line), for 48hrs and then assessed for cell surface expression of MHC II. Isotype control (grey line), RCMV-Wt infected (thin black line), uninfected (thick black line), conditioned supernatant treatment (dashed black line).