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. Author manuscript; available in PMC: 2010 Jun 24.
Published in final edited form as: J Am Chem Soc. 2009 Jun 24;131(24):8434–8445. doi: 10.1021/ja809821x

Table 3.

Multicomponent Synthesis of α-Methyl (Z)-Trisubstituted Allylic Alcohols

graphic file with name nihms120473f14.jpg
entry R1 R3CHO yield (%) product
1 n-Bu CH2O 75a 11
2 (CH2)2OTBS CH2O 77a 12
3 n-Bu Me2CHCH2CHO 92 13
4 n-Bu p-MeC6H4CHO 71 14
5 n-Bu p-ClC6H4CHO 70 15
a

Two equiv para formaldehyde added without removal of the volatile materials.