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. Author manuscript; available in PMC: 2009 Sep 23.
Published in final edited form as: Pharmacogenomics. 2008 Jun;9(6):717–731. doi: 10.2217/14622416.9.6.717

Figure 4. Imino sugar pharmacogenetics.

Figure 4

(Strains) Graphical representation of the differences in the reproductive effect of NB-DNJ between 19 inbred mouse strains. The mice were from the Swiss (FVB/N) and Castle (129S1/SvImJ, A/J, AKR/J, BALB/c, C3H/HeN, CBA/Ca, DBA/2, NZB, NZW and SM/J) families of strains, from the C57 lineage (C57BL/10, C57BR, C57L, C58, MA/My and YBR), and from a mixed background (MRL/Mp). Average standard deviation in percentage abnormal sperm nuclei was 2% (range 0.2–9%, n = 2–3 mice per strain). Indicated are the positions of C57BL/6 and FVB/N mice, which differ widely in their responses to NB-DNJ. (C57 × FVB cross) Indicated are the results of drug administration in individual C57BL/6 × FVB/N intercross mice. As most – but not all – hybrid mice had a similar response as FVB/N mice, the dots around the baseline are overlapping. The effect of NB-DNJ in the remainder of the intercross mice varied widely.

NB-DNJ: N-butyldeoxynojirimycin.