Figure 1.

Comparison of conventional protein structure with thermodynamically defined protein structure. (A) A table (left) containing a subset of the three-dimensional Cartesian coordinates for the human mucosal addressin cell adhesion molecule 1 (PDB id 1gsmA) and its corresponding structural image (right). Positions of α-carbon atoms in Cartesian space are joined by virtual bonds, and N- and C-termini are marked. (B) A table containing a subset of the native state ensemble's four-dimensional thermodynamic coordinates for the same protein. Only the first three dimensions of these coordinates are plotted to visually approximate the protein's thermodynamic structure. Characteristics of the thermodynamic protein structure are graphically different from those of the conventional structure.