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. 2009 Sep 2;97(5):1461–1470. doi: 10.1016/j.bpj.2009.06.020

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Correlation between change in total solvent-accessible surface area and PC1. Each of the 17,484 points represents values from one residue in the thermodynamic database of 120 proteins. The x axis indicates the value of the first principal component. The y axis indicates the total change in average solvent-exposed surface area (ΔASA_ap + ΔASA_pol) for each residue in the ensemble simulated folded to unfolded transition. As discussed in the text, a correlation is evident between PC1 value and solvent-exposed surface area, highlighting the biophysical interpretation of PC1 in terms of area.