Figure 6.
Structural microenvironments of residues exhibiting extreme positions along PC1. (A) Ile156 (PDB id 1jhjA), near a maximum value of PC1, and its immediate unfolding neighbors are displayed as pink-colored sticks. Note that removal of these residues (i.e., upon unfolding) would result in a large amount of newly exposed solvent-accessible surface area; water could potentially fill the entire cavity left by the removal. (B) Residue Pro79 (PDB id 1i71A) and its unfolding neighbors near the smallest PC1 value. Note that no cavity would be left upon unfolding of these residues.