Figure 6.
Contact differences between WT and A4V simulations. All changes shown represent a minimum of a 45% absolute change in contact time relative to WT simulations. (A) Map of the changes in contact time displayed for clarity. (B) The starting structure of the A4V mutant shown with selected changes in contact between residues. The changes displayed represent the shortest pathways of change between the mutation site and the metal-binding residues. Metal-binding residue not shown (Cu2+: H46) did not meet the threshold of 45% change in absolute contact time between WT and A4V simulations.