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Lack of expression of M2-pyruvate kinase in premalignant pancreaticobiliary epithelium: Premalignant lesions showing lack of M2-PK expression pancreatic intraepithelial neoplasia I (× 20) (top panel); pancreatic intraepithelial neoplasia III (× 20) (middle panel); common bile duct with low-grade dysplasia (× 20) (bottom panel).
