Table 6.
PK parameters of MDZ in different population groups (Mean ± SE)
| PK parameters | Population | P value | ||
|---|---|---|---|---|
| Sex | ||||
| Male | Female | |||
| N=116 | 55 | 61 | ||
| AUCiv (μg/L·h) | 150.0±7.2 | 157.5±7.8 | 0.486 | |
| CLiv (L/h·kg) | 0.36±0.02 | 0.43±0.02 | 0.016 | |
| AUCpo (μg/L·h) | 42.7±3.3 | 43.4±3.7 | 0.893 | |
| CLpo (L/h·kg) | 1.57±0.14 | 2.17±0.23 | 0.026 | |
| F (%) | 28.8±1.7 | 27.8±1.8 | 0.687 | |
| Race | ||||
| Caucasians | Africa Americans | |||
| N=114† | 88 | 26 | ||
| AUCiv (μg/L·h) | 155.7±6.4 | 148.0±10.2 | 0.552 | |
| CLiv (L/h·kg) | 0.39±0.02 | 0.41±0.03 | 0.530 | |
| AUCpo (μg/L·h) | 44.0±2.7 | 39.7±6.1 | 0.485 | |
| CLpo (L/h·kg) | 1.84±0.17 | 2.07±0.27 | 0.506 | |
| F | 29.1±1.5 | 25.2±1.9 | 0.191 | |
| Age | ||||
| <65 | ≥65 | |||
| N=114‡ | 62 | 52 | ||
| AUCiv (μg/L·h) | 155.3±7.2 | 151.3±8.1 | 0.711 | |
| CLiv (L/h·kg) | 0.40±0.02 | 0.40±0.02 | 0.828 | |
| AUCpo (μg/L·h) | 44.3±3.6 | 42.3±3.6 | 0.696 | |
| CLpo (L/h·kg) | 1.86±0.18 | 1.91±0.23 | 0.870 | |
| F | 27.3±1.2 | 30.0±2.3 | 0.296 | |
†
2 of 116 subjects were Asians.
‡
2 of 116 subjects had no record of age.