Table II. Cell cycle and apoptosis genomic regions associated with multiple myeloma.
| Genomic Region* | Gene Name | Genes (and # of SNPs) included | Total SNPs | minP** |
|---|---|---|---|---|
| BAX | Bcl2-associated X protein | bax (4), dhdh (3), gys1 (2) | 9 | 0.018 |
| CASP9 | caspase 9 | casp9 (4), dnajc16 (1), ela2b (2) | 7 | 0.025 |
| RIPK1 | receptor-interacting serine-threonine kinase 1 | ripk1 (6), serpinbp1 (1) | 7 | 0.037 |
| BCL2L10 | BCL2-like 10 | bcl2l10 (2), gnb5 (3) | 5 | 0.104 |
| CASP1/4/5 | caspase 1, 4, and 5 | casp1 (4), casp4 (6), casp5 (9), loc440067 (2) | 21 | 0.148 |
| BCL2A1 | BCL2-related protein A1 | bcl2a1 (8) | 8 | 0.155 |
| TP53I3 | tumor protein p53 inducible protein 3 | tp53i3 (2), pfn4 (1), sf3b14 (1) | 4 | 0.155 |
| CCND1 | cyclin D1 | ccnd1 (4) | 4 | 0.236 |
| FAS | TNF receptor superfamily, member 6 | fas (20) | 20 | 0.26 |
| BCL2L1 | BCL2-like 1 | bcl2l1 (3), tpx2 (1) | 4 | 0.417 |
| BCL2L11 | BCL2-like 11 | acoxl (2), bcl2l11 (10) | 12 | 0.467 |
| MDM2 | p53 binding protein homolog | mdm2 (3) | 3 | 0.487 |
| CASP2 | caspase 2 | casp2 (3), clcn1 (1), flj90586 (1) | 5 | 0.544 |
| BCL10 | B-cell CLL/lymphoma 10 | bcl10 (10), c1orf52 (2) | 12 | 0.552 |
| CASP3 | caspase 3 | casp3 (6), flj33167 (3) | 9 | 0.598 |
| CASP14 | caspase 14 | casp14 (6), flj40365 (2) | 8 | 0.603 |
| CASP6 | caspase 6 | casp6 (4), flj20647 (3), pla2g612a (1) | 8 | 0.647 |
| CASP8AP2 | caspase 8 associated protien 2 | casp8ap2 (9), cx62 (4), mdn1 (3) | 16 | 0.691 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | ripk2 (6) | 6 | 0.736 |
| BCL2L2 | BCL2-like 2 | pabpn1 (1), ppp1r3e (1) | 2 | 0.769 |
| FASLG | Fas ligand (TNF superfamily, member 6) | faslg (9) | 9 | 0.772 |
| CASP7 | caspase 7 | casp7 (12) | 12 | 0.809 |
| BCL2 | B-cell CLL/lymphoma 2 | bcl2 (56), fvt1 (5) | 61 | 0.89 |
| MYC | v-myc myelocytomatosis viral oncogene homolog | myc (9) | 9 | 0.924 |
| TP53 | tumor protein p53 | tp53 (1) | 1 | 0.949 |
| PIM1 | pim-1 oncogene | pim1 (1) | 1 | 0.958 |
| CASP8/10 | caspase 8 and 10 | als2cr12 (1), casp8 (9), casp10 (3) | 13 | 0.976 |
*
defined as SNPs between 20kb 5′ of the start of transcription (exon 1) and 10kb 3′ of the end of the last exon were grouped using a binning threshold of r2>0.8;
**
adjusted for age (<50, 50-59, 60-69, ≥ 70 years)