Table IV. Haplotype analyses for significant cell cycle and apoptosis genomic regions associated with multiple myeloma.

Gene Region	Block	Haplotype	Frequency	OR*	95% CI*	Global test*	Order of SNPs
BAX	1	TG	0.74	1.00	reference	0.192	rs2270939 (T>C), rs3765148 (G>A)
		CG	0.18	1.29	0.89 - 1.86
		TA	0.07	1.48	0.85 - 2.58
	2	CT	0.82	1.00	reference	0.279	rs4802527 (C>G), rs11667200 (T>A)
		GA	0.11	0.64	0.37 - 1.12
		GT	0.06	1.18	0.65 - 2.12
		CA	0.01	0.37	0.05 - 2.95
	3	TTGGT	0.37	1.00	reference	0.277	rs11667229 (T>C), rs11667351 (T>G), rs1805419 (G>A), rs1042265 (G>A), rs2270938 (A>T)
		CTGGA	0.29	1.22	0.83 - 1.79
		TTAGA	0.14	1.17	0.41 - 3.28
		CGAAA	0.09	0.47	0.23 - 1.00
		CGAGA	0.03	1.34	0.53 - 3.37
		TTGGA	0.02	1.17	0.41 - 3.28
		CGGGA	0.01	0.87	0.18 - 4.11
		CTAGT	0.01	2.57	0.80 - 8.26
		CTGAA	0.01	0.47	0.06 - 3.79
CASP9	1	GTCTTAA	0.34	1.00	reference	0.011	rs3766160 (G>A), rs12130370 (T>C), rs4646092 (C>T), rs4661636 (C>T), rs4646047 (C>T), rs2020902 (A>G), rs7516435 (A>G)
		ACCCCAG	0.21	1.37	0.92 - 2.03
		GTCCTAA	0.15	0.60	0.34 - 1.05
		GCTCCGA	0.13	0.89	0.53 - 1.49
		GCTCCAA	0.07	1.10	0.57 - 2.12
		GTCCCAG	0.06	1.95	1.01 - 3.74
		GTTCCGA	0.01	0.44	0.06 - 3.38
RIPK1	1	GC	0.63	1.00	reference	0.211	rs7775816 (G>A), rs6596945 (C>A)
		GA	0.20	1.27	0.87 - 1.86
		AC	0.16	1.42	0.95 - 2.13
	2	GG	0.67	1.00	reference	0.547	rs6920337 (G>A), rs2326173 (G>A)
		AA	0.23	0.84	0.58 - 1.22
		GA	0.09	0.78	0.45 - 1.35
		AG	0.01	1.54	0.47 - 5.10
	3	CG	0.66	1.00	reference	0.517	rs10498658 (C>T), rs7765221 (G>A)
		TG	0.26	1.15	0.82 - 1.63
		TG	0.08	1.29	0.76 - 2.17

^*adjusted for age (<50, 50-59, 60-69, ≥ 70 years)