Table 4.

Grade 3–5 toxicities with irinotecan and docetaxel

	Group A (N=20)						Group B (N=32)
	Grade 3		Grade 4		Grade 5		Grade 3		Grade 4		Grade 5
Hemoglobin	-	-	-	-	-	-	1	3%	-	-	-	-
Leukocytes	4	20%	2	10%	-	-	5	16%	2	6%	-	-
Lymphopenia	-	-	-	-	-	-	1	3%	-	-	-	-
Neutrophils	2	10%	4	20%	-	-	2	6%	3	9%	-	-
Transfusion of packed red blood cells	1	5%	-	-	-	-	3	9%	-	-	-	-
Hypotension	-	-	-	-	-	-	-	-	2	6%	-	-
Thrombosis/embolism	-	-	-	-	-	-	1	3%	-	-	-	-
Cardiac-other	-	-	-	-	-	-	-	-	1	3%	-	-
Fatigue	2	10%	-	-	-	-	7	22%	-	-	-	-
Fever	-	-	-	-	-	-	1	3%	-	-	-	-
Prothrombin time	-	-	-	-	-	-	1	3%	-	-	-	-
Anorexia	1	5%	1	5%	-	-	3	9%	1	3%	-	-
Dehydration	6	30%	-	-	-	-	3	9%	-	-	1	3%
Gastritis	1	5%	-	-	-	-	-	-	-	-	-	-
Stomatitis	1	5%	-	-	-	-	-	-	-	-	-	-
Nausea	-	-	-	-	-	-	2	6%	-	-	-	-
Vomiting	1	5%	-	-	-	-	1	3%	1	3%	-	-
Diarrhea	8	40%	1	5%	-	-	3	9%	1	3%	-	-
Gastrointestinal bleeding	1	5%	-	-	-	-	-	-	-	-	-	-
Alkaline phosphatase	1	5%	-	-	-	-	-	-	-	-	-	-
Hypoalbuminemia	-	-	-	-	-	-	1	3%	-	-	-	-
Febrile neutropenia	1	5%	-	-	-	-	-	-	-	-	-	-
Infection with grade 3 –4 neutropenia	1	5%	1	5%	-	-	-	-	1	3%	1	3%
Infection with unknown neutrophil count	-	-	-	-	-	-	1	3%	-	-	-	-
Infection without neutropenia	-	-	-	-	-	-	-	-	2	6%	1	3%
Hypokalemia	1	5%	-	-	-	-	1	3%	-	-	-	-
Hyponatremia	7	35%	-	-	-	-	3	9%	-	-	-	-
Depressed level of consciousness	-	-	-	-	-	-	2	6%	-	-	-	-
Dizziness/lightheadedness	-	-	-	-	-	-	1	3%	-	-	-	-
Anxiety/agitation	1	5%	-	-	-	-	1	3%	-	-	-	-
Hypoxia	1	5%	-	-	-	-	-	-	-	-	-	-
Pleural effusion	1	5%	-	-	-	-	-	-	-	-	-	-
Pulmonary-other	-	-	1	5%	-	-	-	-	-	-	-	-
Syncope	-	-	-	-	-	-	1	3%	-	-	-	-
Abdominal pain	-	-	-	-	-	-	1	3%	-	-	-	-
ARDS	-	-	-	-	-	-	-	-	1	3%	-	-
Dyspnea	-	-	-	-	-	-	1	3%	1	3%	-	-
Creatinine	-	-	1	5%	-	-	1	3%	1	3%	-	-
WORST DEGREE	9	45%	6	30%	-	-	14	44%	5	16%	3	9%