Contractile activity of oxotremorine-M in ilea from the guinea pig and from wild type, M2 KO, and M3 KO mice. The data represent the mean values ± SEM from experiments on 13 guinea pigs, 39 wild-type mice, 25 M2 KO mice, and 25 M3 KO mice. The responses in the guinea-pig ileum have been normalized relative to Emax and those in mice to the Emax in wild type