Table 4.

Effect of 4-DAMP mustard treatment (40 nM) in combination with AF-DX 116 (4 μM) on the contractile activity of oxotremorine-M in mouse ileum

	Control	4-DAMP mustard
	pEC50	pEC50	Emax (%)a
Wild type
1 h treatment (9)	6.59 ± 0.08	6.62 ± 0.17	34 ± 8
2 h treatment (7)	6.96 ± 0.06	6.89 ± 0.14	43 ± 9
M2 KO
2 h treatment (6)	6.39 ± 0.09	5.80 ± 0.16	33 ± 9
M3 KO
2 h treatment (5)	7.15 ± 0.08	7.36 ± 0.09	74 ± 3

The data are from Fig. 2 and represent the mean values ± SEM. The numbers in parentheses beside each mouse strain denote the number of experiments. The E_max values in 4-DAMP mustard-treated ileum are normalized relative to that measured under control conditions

^aE_max values and their SEM have been normalized relative to the average E_max value of control