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. Author manuscript; available in PMC: 2009 Sep 23.
Published in final edited form as: Biochim Biophys Acta. 2008 Jun 17;1781(9):448–458. doi: 10.1016/j.bbalip.2008.05.005

Figure 1.

Figure 1

Sphingolipid metabolism. LCBs formed from either sphingolipid de novo synthesis (step 1, 2) or from sphingolipid degradation (step 9, 7) can be phosphorylated by sphingosine kinases (step 3). The formed LCBPs can then be dephosphorylated by sphingosine-1-phosphate phosphatase or type 2 phosphatidate phosphohydrolase activity (step 4). Alternatively, LCBPs can be irreversible cleaved by SPL, thereby yielding an alkyl aldehyde and phosphoethanolamine.