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LCBPs metabolized by SPL. Dihydrosphingosine-1-phosphate, sphingosine-1-phosphate and phytosphingosine-1-phosphate are the major LCBPs found in mammals and yeast and the naturally occurring D-erythro isomer of these compounds is metabolized by SPL. SPL also metabolizes certain forms of LCBPs containing methyl groups at C4 or C5. SPL shows broad specificity towards the chain length of the LCBP and medium and long chain compounds are used as substrates.
