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Sequence alignment of SPL. ClustalW alignment of Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Dictyostelium discoideum and Leishmania major SPL. The underlined regions indicate the ER luminal domain (green), the transmembrane spanning domain (red) and the predicted pyridoxal-phosphate binding domain (yellow). Black shading indicates identical residues. Gray shading indicates biochemically similar residues.
