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SPL downregulation in intestinal tumorigenesis. Immunohistochemistry with a murine SPL-specific antibody used as described previously shows robust SPL expression in normal differentiated epithelial cells of the villus of the small intestine (brown staining) in the ApcMin/+ mouse model of colon cancer, whereas undifferentiated adenomatous areas in the submucosa do not express SPL [60]. (Left) hematoxylin & eosin; (Right) immunohistochemistry.
