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. Author manuscript; available in PMC: 2009 Sep 23.
Published in final edited form as: Circ Res. 2008 May 22;102(12):1512–1519. doi: 10.1161/CIRCRESAHA.108.172064

Figure 4. OxLDL-induced platelet activation of platelets is mediated by JNK and src kinases.

Figure 4

Figure 4

Figure 4

Figure 4

(A-C) Human platelets were incubated with the specific JNK inhibitor SP600125 (final concentration of 20 uM) for 30 minutes prior to incubation with 50 μg/ml oxLDL (A) or 10 μM ADP (B) or 2 μM TRAP (SFLLRN) (C) and analyzed by flow cytometry with PE-labeled anti-P-selectin antibody. (D) Platelets were incubated with src family kinase inhibitor AG1879 (10 uM) for 30 minutes prior to incubation with 50 μg/ml oxLDL. Control platelets were treated with the vehicle, DMSO. Results are representative of at least 3 independent experiments from different donors. The bar graph represents mean fluorescence intensities measured with flow cytometry. The error bars are expressed as Mean ± SE. n=4 for A or n=3 for B, C, D.