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. 2009 Jul 30;28(18):2835–2845. doi: 10.1038/emboj.2009.209

Figure 2.

Figure 2

The second leucine zipper structure of JIP4. (A) Schematic representation of the JIP4 protein. (B) Sequence alignement of JIP3 and JIP4. The heptad repeats, the characteristic leucine residues at position ‘d' in each heptad, and their respective sequence numbers are indicated. On the JIP4 sequence, the ARF6-binding site (residues A412–D432) is highlighted in grey. (C) The JIP4-LZII structure is shown (with only one ARF6 molecule bound) aligned along the JIP3/JIP4 sequence alignment. It should be noted that the C-terminal part of the linker between the histidine tag and JIP4 has defined density at the N-terminus of the chain C and thus has been modelled (residues A386–F391), whereas the ninth heptad repeats of both monomers are not seen in the density and are not modelled.