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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2009 Apr 16;20(8):1504–1513. doi: 10.1016/j.jasms.2009.04.004

Fig. 4.

Fig. 4

Quantitative analysis of the interdomain cross-linked peptides upon Akt-inhibitor (PI analog) interaction. MALDI-TOF-TOF MS spectrum was obtained from 16O-labeled inhibitor-interacted sample without (A) or with liposomes (B), mixed with 18O-labeled non-interacted control. The schematic presentation illustrates the effect of the inhibitor on Akt interdomain conformation and membrane translocation.