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. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: J Am Chem Soc. 2009 Apr 15;131(14):5257–5263. doi: 10.1021/ja809419f

Figure 4A.

Figure 4A

General view of the proposed C3 RNA reaction center. Color code: black - bottom strand, C11-G17; top strands: G1-G2 - magenta, C24-U26 - red; blue - (L)-5'-Phenylalanyl adenylate, (L)-PheAMP; dark red - oxygen atoms of ribose rings; green - phosphorus atoms; cyan - reactive carbon, oxygen and Watson-Crick hydrogen bonds. Adenine of (L)-PheAMP and the base of U13 are turned away from the reaction center, Acceptor U26 stacks against G1. Phenyl ring (Ph) of phenylalanine is close but perpendicular to U26; Ph is closer to the viewer than C25, so no Ph-C25 stacking interactions occur.