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Agents targeting the EGFR family under investigation or approved for metastatic breast cancer
| Agent | Class of agent | Target | Stage of development in breast cancer |
| Trastuzumab | Monoclonal antibody | HER2 | Approved |
| Lapatinib | TKI | EGFR, HER2 | Approved |
| Erlotinib | TKI | EGFR | II |
| Cetuximab | Monoclonal antibody | EGFR | II |
| Gefitinib | TKI | EGFR | Discontinued |
EGFR, epidermal growth factor receptor; HER2, human epidermal growth factor receptor 2; TKI, tyrosine kinase inhibitor.
