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. 2009 Aug 28;11(4):208. doi: 10.1186/bcr2237

Table 5.

Other agents under investigation in metastatic breast cancer

Agent Class of agent Stage of development
Tipifarnib Farnesyl transferase inhibitor Inhibits Ras activation II
Deforolimus mTOR inhibitor II
Everolimus mTOR inhibitor II
Sirolimus mTOR inhibitor I
Temsirolimus mTOR inhibitor Discontinued
KU-59436 PARP inhibitor II
BSI-2011 PARP inhibitor II
AG-14699 PARP inhibitor II

mTOR, mammalian target of rapamycin; PARP, poly-ADP ribose polymerase.