Table 3.

Univariate and multivariate analyses of gene-expression prognostic factors (as continuous variables) for locoregional recurrences

Gene expression by quantitative rt-PCR (continuous variables)	Univariate analysis		Multivariate analysis
	HR (RR) [95% CI]	P	HR (RR) [95% CI]	P
Estrogen receptor-α	1.22 [0.90–1.66]	0.15
Estrogen receptor-β	0.61 [0.39–0.95]	0.04		0.54
Progesterone receptor	1.13 [0.88–1.45]	0.32
HER1	0.65 [0.37–1.13]	0.10		0.72
HER2	0.89 [0.64–1.25]	0.49
HER3	1.06 [0.55–2.02]	0.87
HER4	1.22 [0.91–1.63]	0.14
MKI 67	0.89 [0.61–1.30]	0.56
Cyclin E1	0.81 [0.48–1.36]	0.43
Cyclin E2	0.75 [0.49–1.14]	0.18
GATA 3	1.61 [0.95–2.73]	0.04	1.49 [0.92–2.39]	0.06
IGF1R	1.41 [0.93–2.14]	0.13
NCoR	0.90 [0.38–2.15]	0.82
NCoA3/AIB1	0.51 [0.21–1.22]	0.14
CYP19 (aromatase)	0.48 [0.28–0.80]	0.003	0.49 [0.29–0.82]	0.003
Skp2	0.52 [0.23–1.17]	0.10		0.18
CAF-1 p150	1.00 [0.48–2.12]	1.00
CAF-1 p60	1.00 [0.97–1.03]	0.94

RR = relative risk for locoregional recurrence calculated with the nonparametric Cox model; CI = confidence interval; HER = human epidermal receptor. Because of lack of prognostic values of the clinical variables in univariate analysis, none was entered in the multivariate analysis.