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. 2009 Aug 24;11(4):R61. doi: 10.1186/bcr2352

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Copyright © 2009 Heckman-Stoddard et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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P190B^+/+Neu tumors and p190B^+/-Neu tumors have similar histology and growth, but differential signaling. (a) Histological section of p190B^+/+Neu tumors and p190B^+/-Neu tumors stained with hematoxylin and eosin (H&E). Arrows point to vasculature. Scale bar = 50 μm. (b) Growth curve of p190B^+/+Neu tumors and p190B^+/-Neu tumors. No statistical difference. (c) Immunoblotting for phosphorylated Rho kinase (pROK), Rho kinase (ROK), phosphorylated p21-activated kinase (p-PAK)1/2, and total ERK and actin as loading controls in four independent tumors from each indicated genotype. Quantification of western blots is graphed. (d) Quantification of active GTPase levels in tumor tissue. Analysis was carried out using Image J software. Error bars, standard error of the mean.