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. 2009 Aug 24;11(4):R61. doi: 10.1186/bcr2352

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Copyright © 2009 Heckman-Stoddard et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Angiogenesis defect in p190B^+/-Neu tumors is rescued by wild-type stroma. (a) Number of days to tumor burden following transplantation of a designated genotype tumor piece into the cleared fatpad of a SCID/Beige mouse. Decreased time to tumor burden was statistically significant in p190B^+/-Neu tumor transplants. (b) Percentage take rate of p190B^+/+Neu transplants and p190B^+/-Neu transplants. No statistical difference was seen between genotypes. (c) Number of vessels per 100× section of tumor stained with von Willebrand factor (VWF) was quantified. No statistical difference between genotypes was detected. (d) Representative pictures of VWF immunofluorescence (red) and dapi (blue) in the two different genotypes as indicated. Arrows mark blood vessels. Scale bar = 100 μm. (e) Percentage take rate of p190B^+/-Neu tumors into a p190B^+/+Neu host and of p190B^+/+Neu tumors into a p190B^+/-Neu host. The p190B^+/-Neu tumors had a 100% take rate, while the p190B^+/+Neu tumors had a 0% take rate. Statistically significant difference P < 0.0001. Error bars, standard error of the mean.