Table 1.
IC50 values of DZNep and TSA on BRCA1-proficient vs. BRCA1-deficient mammary tumor cells
| Cell line | nM DZNep (SEM) | nM TSA (SEM) |
| BRCA1-proficient | ||
| KP-3.33 | 3202 (284) | 27 (1.2) |
| KP-6.3 | 3467 (277) | 35 (1.5) |
| KP-7.7 | 2163 (63) | 25 (3.8) |
| BRCA1-deficient | ||
| KB1P-3.12 | 154 (14) | 26 (2.4) |
| KB1P-30.3 | 163 (13) | 17 (0.6) |
| KB1P-40.1 | 171 (9) | 36 (3.4) |
| Ratio (KP/KB1P) | 18.1* | 1.1 |
| Significance | < 0.0001 | 0.5 |
Note: Values between brackets represent the standard error of the mean (SEM) of at least three independent experiments. Ratio: Average half maximal inhibitory concentration (IC50) values of 3-deazaneplanocin A (DZNep) and trichostatin A (TSA) for the K14cre;Brca1w.t/w.t;p53F/F (KP) lines were compared with average IC50 values of the K14cre;Brca1F/F;p53F/F (KB1P) lines. *Significance: P < 0.01 (t-test).