Table 2.
IC50 values of DZNep on BRCA1-deficient vs. BRCA1-reconstituted mammary tumor cells
| Cell line | nM DZNep (SEM) |
| BRCA1-proficient | |
| KP-6.3 | 3523 (463) |
| BRCA1-reconstituted | |
| KB1PR-3.12 E3 | 1954 (744) |
| KB1PR-3.12 F4 | 829 (331) |
| BRCA1-deficient | |
| KB1P-3.12 | 135 (13) |
| KB1P40.1 | 187 (33) |
| Ratio (BRCA1-reconst. vs. deficient) | 8.7* |
| Significance | 0.003 |
Note: Values between brackets represent the standard error of the mean (SEM) of at least three independent experiments. Ratio: Average half maximal inhibitory concentration (IC50) values of 3-deazaneplanocin A (DZNep) for the K14cre;Brca1F/F;p53F/F (KB1P) lines were compared with average IC50 values of the KB1P lines. *Significance: P < 0.01 (t-test).