Figure 2.
Unfractionated heparin and enoxaparin reduced lung stretch – induced neutrophil sequestration. The mice were ventilated at VT 6 ml or VT 30 ml for 5 hours with room air. Unfractionated heparin, 200 IU/kg or 400 IU/kg, and enoxaparin, 4 mg/kg or 8 mg/kg, was given subcutaneously 30 minutes before ventilation. (a) Neutrophils in bronchoalveolar lavage (BAL) fluid of lung tissue (n = 6 per group). (b) Myeloperoxidase (MPO) assay of lung tissue (n = 6 per group). *P < 0.05 versus control, nonventilated mice; † P < 0.05 versus all other groups; ‡ P < 0.05 versus 200-IU/kg or 4-mg/kg groups. H = unfractionated heparin; LMWH = enoxaparin.