Figure 4.
PAI-1–deficient mice reduced lung stretch–induced microvascular leak, lung edema, and total lung injury. Wild-type or PAI-1-/- mice were ventilated at VT 30 ml for 5 hours with room air. (a) EBD analysis of lung tissue (n = 6 per group). (b) Lung water measured by lung wet- to dry-weight ratio (n = 6 per group). (c) Total lung-injury scores of H&E-stained paraffin sections (n = 6 per group). * P < 0.05 versus control, nonventilated mice; † P < 0.05 versus PAI-1-/- mice. EBD = Evans blue dye; PAI-1 = plasminogen-activator inhibitor-1.