Table 1.
Demographic data and clinical characteristics
| All Patients (n = 32) |
Hospital Survivors (n = 25) |
Hospital Non-survivors (n = 7) |
P value | |
|---|---|---|---|---|
| Age (years) | 68 (55 to 79) | 68 (55 to 81) | 75 (55 to 80) | NS (0.293) |
| Gender (M/F) | 12/20 | 9/16 | 3/4 | NS (1.000) |
| BUN | 15.5 (10.5 to 36.5) | 14 (8.5 to 20.5) | 40 (17 to 80) | < 0.001 |
| Serum creatinine (mg/dl) | 1.1 (0.6 to 1.9) | 0.9 (0.6 to 1.4) | 3.7 (2 to 4.2) | < 0.001 |
| Bilirubin (mg/dl) | 1.6 (0.8 to 3.2) | 1.5 (0.7 to 2.6) | 5.1 (1.2 to 11.5) | 0.006 |
| Albumin (g/l) | 2.8 (2.4 to 3) | 2.8 (2.4 to 3.1) | 2.6 (2.3 to 2.8) | NS (0.090) |
| INR | 1.2 (1.2 to 1.4) | 1.2 (1.2 to 1.4) | 1.3 (1.2 to 1.5) | NS (0.399) |
| MAP (mmHg) | 79 (60 to 90) | 81 (68 to 92) | 60 (57 to 75) | 0.041 |
| SOFA score on the day of SST | 5 (3 to 9) | 4 (2.3 to 6.8) | 12 (10 to 16) | 0.001 |
| APACHE II score on the day of SST | 15 (10 to 20) | 14 (9.5 to 18) | 20 (15 to 36) | 0.006 |
| Ranson score | 5 (3 to 6) | 4 (3 to 5.5) | 8 (5 to 9) | 0.005 |
| CIRCI (%) | 11 (34.4) | 6 (24) | 5 (71.4) | 0.032 |
| Baseline cortisol (μg/dL) | 21.6 (17.1 to 36) | 20.7 (16.4 to 31.6) | 28 (19.1 to 39.1) | NS (0.368) |
| Peak cortisol (μg/dL) | 39.2 (32.1 to 46.8) | 39.2 (32.5 to 47.1) | 39.1 (29.7 to 46) | NS (0.316) |
| Cortisol increment (μg/dL) | 14.5 (3.3 to 25.3) | 17.4 (8.3 to 27.1) | 7.2 (1.7 to 12) | 0.019 |
| Bacteremia (%) | 14 (43.8) | 10 (40) | 4 (57.1) | NS (0.669) |
| Number of organ dysfunction on the day of SST | 2 (1 to 3) | 1 (1 to 2) | 4 (3 to 5) | < 0.001 |
| Respiratory dysfunction (%) | 23 (71.9) | 16 (69.6) | 7 (100) | NS (0.149) |
| Coagulation dysfunction (%) | 7 (21.9) | 3 (12) | 4 (57.1) | 0.026 |
| Cardiovascular dysfunction (%) | 10 (31.3) | 5 (20) | 5 (71.4) | 0.019 |
| CNS dysfunction (%) | 14 (43.8) | 8 (32) | 6 (85.7) | 0.0287 |
| Renal dysfunction (%) | 12 (37.5) | 5 (20) | 7 (100) | < 0.001 |
APACHE = Acute Physiology and Chronic Health Evaluation; BUN = blood urea nitrogen; CIRCI = critical illness related corticosteroid insufficiency; CNS = central nervous system; F = female; INR = international normalized ratio; M = male; MAP = mean arterial pressure; NS = not significant; SOFA = sequential organ failure assessment; SST = short corticotropin stimulation test.