Table 2.
Demographic data and clinical characteristics grouped according to adrenal function
| All patients (n = 32) |
Adrenal insufficiency (n = 11) |
Normal adrenal function (n = 21) |
P value | |
|---|---|---|---|---|
| Age (years) | 68 (55 to 80) | 73 (58 to 80) | 68 (55 to 81) | NS (0.685) |
| Gender (M/F) | 12/20 | 4/7 | 8/13 | NS (0.923) |
| ICU mortality (%) | 6 (18.8) | 5 (45.5) | 1 (4.8) | 0.011 |
| Hospital mortality (%) | 7 (21.9) | 5 (45.5) | 2 (9.5) | 0.032 |
| BUN (mg/dl) | 15.5 (10.5 to 36.5) | 23 (12 to 45) | 15 (8.5 to 23.5) | NS (0.293) |
| Serum creatinine (mg/dl) | 1.1 (0.6 to 1.9) | 2.5 (1.1 to 3.7) | 0.9 (0.6 to 1.3) | 0.003 |
| Bilirubin (mg/dl) | 1.6 (0.8 to 3.2) | 5.1 (1.9 to 9.6) | 1.4 (0.7 to 2.0) | 0.004 |
| Albumin (g/l) | 2.8 (2.4 to 3) | 2.8 (2.4 to 2.8) | 2.8 (2.2 to 3.1) | NS (0.839) |
| INR | 1.2 (1.2 to 1.4) | 1.3 (1.2 to 1.5) | 1.2 (1.2 to 1.3) | NS (0.568) |
| MAP (mmHg) | 79 (60 to 90) | 58 (57 to 60) | 84 (79 to 93) | < 0.001 |
| SOFA score on the day of SST | 5 (3 to 9) | 11 (7 to 15) | 4 (2 to 6) | < 0.001 |
| APACHE II score on the day of SST | 15 (10 to 20) | 20 (10 to 27) | 15 (11 to 18) | 0.018 |
| Ranson score | 5 (3 to 6) | 7 (5 to 9) | 4 (3 to 5) | < 0.001. |
| Necrosis (%) | 20 (62.5) | 11 (100) | 9 (42.9) | 0.002 |
| Bacteremia (%) | 14 (43.8) | 9 (81.8) | 5 (23.8) | 0.003 |
| Number of organ dysfunction on the day of SST | 2 (1 to 3) | 4 (2.5 to 5) | 1 (1 to 2) | < 0.001 |
| Respiratory dysfunction (%) | 23 (71.9) | 9 (81.8) | 14 (66.7) | NS (0.441) |
| Coagulation dysfunction (%) | 7 (21.9) | 7 (63.6) | 0 (0) | < 0.001 |
| CV dysfunction (%) | 10 (31.3) | 9 (81.8) | 1 (4.8) | < 0.001 |
| CNS dysfunction (%) | 14 (43.8) | 6 (54.5) | 8 (38.1) | NS (0.465) |
| Renal dysfunction (%) | 12 (37.5) | 7 (63.6) | 5 (23.8) | 0.027 |
APACHE = Acute Physiology and Chronic Health Evaluation; BUN = blood urea nitrogen; CIRCI = critical illness related corticosteroid insufficiency; CNS = central nervous system; CV = cardiovascular; F = female; ICU = intensive care unit; INR = international normalized ratio; M = male; MAP = mean arterial pressure; NS = not significant; SOFA = sequential organ failure assessment; SST = short corticotropin stimulation test.