Table 3.
Comparison of the WA and CORE cohorts
| Sepsis | Pneumonia | Trauma | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable |
WA (n = 111) |
CORE (n = 1429) |
P |
WA (n = 82) |
CORE (n = 1066) |
P |
WA (n = 176) |
CORE (n = 2114) |
P |
| Age, years (SD) | 54.6 (16.9) | 60.1 (17.9) | 0.001 | 56.1 (15.7) | 61.1 (17.8) | 0.003 | 35.9 (16.27) | 42.6 (19.3) | 0.001 |
| Male, number (%) | 54 (48.6) | 792 (55.4) | 0.20 | 47 (57.3) | 588 (55.2) | 0.73 | 137 (77.8) | 1599(75.6) | 0.58 |
| Median APACHE II score (IQR) | 22.0 (11.0) | 21.0 (13.7) | 0.90 | 20 (9.3) | 19 (10) | 0.80 | 13.0 (9.8) | 11.0 (10.0) | 0.001 |
| Median APACHE II predicted mortality, % (IQR) | 45.2 (37.6) | 41.6 (43.6) | 0.78 | 35.5 (28.3) | 32.2 (31.0) | 0.80 | 6.3 (12.1) | 6.2 (12.4) | 0.12 |
| Chronic respiratory disease, number (%) | 2 (1.8) | 126 (8.8) | 0.006 | 8 (9.8) | 206 (19.3) | 0.04 | 1 (0.6) | 58 (2.7) | 0.08 |
| Chronic cardiovascular disease, number (%) | 1 (0.9) | 140 (9.8) | 0.001 | 1 (1.2) | 93 (8.7) | 0.01 | 0 (0) | 43 (2.0) | 0.07 |
| Chronic renal disease, number (%) | 3 (2.7) | 105 (7.3) | 0.08 | 3 (3.7) | 27 (2.5) | 0.47 | 0 (0) | 3 (0.1) | 1.00 |
| Chronic liver disease, number (%) | 0 (0) | 59 (4.1) | 0.02 | 0 (0) | 25 (2.3) | 0.25 | 0 (0) | 12 (0.6) | 0.62 |
| Immunosuppressed state, number (%) | 7 (6.3) | 185 (12.9) | 0.05 | 5 (6.1) | 101 (9.4) | 0.43 | 0 (0) | 38 (1.8) | 0.11 |
| Median length of ICU stay, days (IQR) | 5.1 (7.0) | 2.4 (4.9) | 0.001 | 7 (8.3) | 3.61 (6.6) | 0.001 | 4.0 (9.8) | 2.0(4.7) | 0.001 |
| Median length of hospital stay, days (IQR) | 18.0 (24.0) | 9.9 (16.1) | 0.001 | 15 (11.8) | 11.4 (13.5) | 0.01 | 18.0 (26.8) | 8.0 (16.7) | 0.001 |
| ICU mortality, number (%)* | 24 (21.6) | 319 (23.0) | 0.82 | 13 (15.9) | 169 (16.2) | 1.00 | 17 (9.7) | 163 (8.0) | 0.47 |
| 28-day mortality, number (%) | 28 (23.4) | 355 (27.9) | 0.58 | 18 (22.0) | 190 (20.2) | 0.67 | 18 (10.2) | 195 (9.7) | 0.79 |
| Hospital mortality, number (%)* | 35 (31.5) | 417 (30.7) | 0.83 | 20 (24.4) | 230 (23.0) | 0.79 | 20 (11.4) | 210 (10.5) | 0.70 |
# P values were generated by either Mann-Whitney or chi-squared test.
* Intensive care unit (ICU) and hospital mortality outcome of CORE cohort was available only in 2031 and 2010 cases, respectively.
APACHE = Acute Physiology and Chronic Health Evaluation; IQR = interquartile range; SD = standard deviation.