Table 2.
Case mix for admissions with haematological malignancy by diagnostic category
| AML (n = 622) | ALL (n = 272) | CMLL (n = 310) | ||
|---|---|---|---|---|
| Age, mean (SD) | 49.8 (16.8) | 33.5 (20.1) | 61.7 (16.1) | |
| Male, n (%) | 331 (53.2) | 143 (52.6) | 205 (66.1) | |
| APACHE II Acute Physiology Score, mean (SD) | 20.1 (6.9) | 18.6 (6.9) | 17.2 (6.9) | |
| APACHE II score, mean (SD) | 26.3 (7.6) | 23.8 (7.2) | 24.9 (7.6) | |
| ICNARC physiology score, mean (SD) | 26.5 (11.1) | 24.1 (11.2) | 23.7 (11.4) | |
| Number of organ system failures, mean (SD) | 1.9 (1.2) | 1.7 (1.1) | 1.5 (1.1) | |
| Mechanically ventilated at any time during first 24 hours in the ICU, n (%) | 329 (53.1) | 129 (47.6) | 165 (53.4) | |
| Severe sepsis, n (%) | 284 (45.7) | 121 (44.5) | 137 (44.2) | |
| Physiology | ||||
| Lowest platelet count (× 109/l), median (IQR) | 26 (13 to 51) | 34 (19 to 62) | 61 (34 to 121) | |
| Lowest white blood cell count (× 109/l), median (IQR) | 2.3 (0.2 to 16.1) | 1.9 (0.2 to 6.8) | 10.3 (3.1 to 34.6) | |
| Mortality, n (%) | ||||
| Unit | 341 (54.8) | 116 (42.7) | 126 (40.7) | |
| Acute hospitala | 398 (67.3) | 141 (55.5) | 165 (56.9) | |
| Unit length of stay (days), median (IQR) | ||||
| Unit survivor | 2.8 (1.0 to 5.6) | 2.2 (1.0 to 4.9) | 2.2 (1.0 to 6.1) | |
| Unit nonsurvivor | 1.5 (0.6 to 4.4) | 3.4 (1.0 to 10.2) | 1.5 (0.4 to 6.3) | |
| All | 1.9 (0.8 to 5.3) | 2.6 (1.0 to 6.7) | 1.9 (0.8 to 6.1) | |
| Acute hospital length of stay (days)a, median (IQR) | ||||
| Hospital survivor | 38 (27 to 62) | 39 (21 to 61) | 19 (11 to 41) | |
| Hospital nonsurvivor | 15 (3 to 27) | 23 (8 to 45) | 9 (3 to 24) | |
| All | 22 (8 to 39) | 29 (13 to 51) | 15 (7 to 33) | |
| Readmission within the same acute hospital stay, n (%) | 28 (4.5) | 14 (5.2) | 18 (5.8) | |
| Acute hospital mortality by number of organ system failures, n (%) | ||||
| 0 organ failures | 24 (47.1) | 10 (27.8) | 16 (29.6) | |
| 1 organ failure | 99 (54.4) | 39 (48.2) | 51 (45.5) | |
| 2 organ failures | 114 (65.9) | 49 (60.5) | 44 (67.7) | |
| 3 organ failures | 105 (85.4) | 31 (79.5) | 38 (90.5) | |
| 4 organ failures | 47 (88.7) | 9 (64.3) | 15 (93.8) | |
| 5 organ failures | 9 (100.0) | 3 (100.0) | 1 (100.0) | |
| Hodgkin's lymphoma (n = 216) | Non-Hodgkin's lymphoma (n = 1,007) | Bone marrow transplant (n = 156) | Myeloma (n = 397) | |
| Age, mean (SD) | 50.7 (17.9) | 56.3 (15.8) | 40.8 (14.7) | 63.0 (11.2) |
| Male, n (%) | 123 (56.9) | 611 (60.7) | 83 (53.2) | 244 (61.5) |
| APACHE II Acute Physiology Score, mean (SD) | 16.7 (7.0) | 17.2 (7.4) | 18.5 (8.6) | 17.1 (7.5) |
| APACHE II score, mean (SD) | 23.2 (7.5) | 24.1 (8.0) | 23.4 (9.5) | 24.3 (7.9) |
| ICNARC physiology score, mean (SD) | 23.2 (11.0) | 24.0 (10.9) | 24.0 (12.4) | 24.2 (10.8) |
| Number of organ system failures, mean (SD) | 1.5 (1.2) | 1.5 (1.2) | 1.7 (1.3) | 1.7 (1.3) |
| Mechanically ventilated at any time during first 24 hours in the ICU, n (%) | 115 (53.5) | 528 (52.7) | 69 (45.1) | 209 (52.8) |
| Severe sepsis, n (%) | 101 (46.8) | 414 (41.1) | 68 (43.6) | 146 (36.8) |
| Physiology | ||||
| Lowest platelet count (× 109/l), median (IQR) | 75 (29 to 188) | 82 (33 to 184) | 37 (19 to 62) | 95 (47 to 161) |
| Lowest white blood cell count (× 109/l), median (IQR) | 6.1 (2.1 to 10.5) | 6.3 (1.8 to 13.6) | 3.7 (0.6 to 8.2) | 4.7 (1.9 to 8.8) |
| Mortality, n (%) | ||||
| Unit | 119 (55.1) | 492 (48.9) | 74 (47.4) | 151 (38.0) |
| Acute hospitala | 142 (71.0) | 625 (66.2) | 93 (65.0) | 227 (60.1) |
| Unit length of stay (days), median (IQR) | ||||
| Unit survivor | 2.7 (1.2 to 5.4) | 2.9 (1.3 to 6.7) | 2.6 (1.1 to 8.3) | 2.9 (1.2 to 8.1) |
| Unit nonsurvivor | 4.5 (1.2 to 8.7) | 2.7 (0.9 to 6.4) | 3.9 (1.1 to 7.7) | 2.8 (0.7 to 7.4) |
| All | 3.4 (1.2 to 7.2) | 2.7 (1.1 to 6.4) | 3.0 (1.1 to 7.9) | 2.9 (1.1 to 7.7) |
| Acute hospital length of stay (days)a, median (IQR) | ||||
| Hospital survivor | 24 (12 to 44) | 29 (15 to 53) | 32 (17 to 63) | 34 (18 to 55) |
| Hospital nonsurvivor | 15 (6 to 26) | 15 (6 to 30) | 28 (13 to 46) | 14 (5 to 25) |
| All | 17 (8 to 35) | 19 (9 to 35) | 29 (15 to 54) | 20 (9 to 38) |
| Readmission within the same acute hospital stay, n (%) | 16 (7.4) | 59 (5.9) | 11 (7.1) | 10 (2.5) |
| Acute hospital mortality by number of organ system failures, n (%) | ||||
| 0 organ failures | 26 (54.2) | 90 (43.7) | 6 (25.0) | 24 (32.4) |
| 1 organ failure | 43 (71.7) | 182 (60.3) | 27 (62.8) | 54 (49.1) |
| 2 organ failures | 38 (70.4) | 197 (75.2) | 28 (71.8) | 70 (68.0) |
| 3 organ failures | 24 (88.9) | 102 (87.9) | 13 (72.2) | 41 (77.4) |
| 4 organ failures | 10 (100.0) | 41 (93.2) | 17 (100.0) | 27 (100.0) |
| 5 organ failures | 1 (100.0) | 13 (92.9) | 2 (100.0) | 11 (100.0) |
Only admissions with a haematological diagnosis as the primary, secondary or ultimate reason for admission are included. The numbers with each diagnosis are greater than in the logistic regression model because admissions missing hospital outcome and readmissions are excluded from the regression analysis. AML: acute myelogenous leukaemia; ALL: acute lymphocytic leukaemia; APACHE: Acute Physiology and Chronic Health Evaluation; APS: Acute Physiology Score; CI: confidence interval; CMLL: chronic myelogenous or chronic lymphocytic leukaemia; ICNARC: Intensive Care National Audit & Research Centre; ICU: intensive care unit; IQR: interquartile range; SD: standard deviation. aExcluding readmissions within the same acute hospital stay.