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. 2009 Aug 25;13(4):R137. doi: 10.1186/cc8016

Table 4.

Multivariate logistic regression analysis for admissions to critical care units with haematological malignancya

Number of admissions Number of deaths Percentage of deaths Adjusted

Odds ratio (95% CI) P value
Age < 0.001
 <45 years 1,512 831 55.0 1.14 (1.09 to 1.20)
 45 to 54 years 1,053 622 59.1 Per 10-year increase
 55 to 64 years 1,716 1,006 58.6
 65 to 74 years 1,852 1,171 63.2
 75+ years 1,028 609 59.2
Sex 0.742
 Female 2,818 1,709 60.7 1.02 (0.89 to 1.18)
 Male 4,343 2,530 58.3 Reference
Diagnostic categoryb < 0.001
 Bone marrow transplant 143 93 65.0 1.88 (1.00 to 3.53)
 ALL 254 141 55.5 Reference
 AML 591 398 67.3 1.37 (0.86 to 2.20)
 CLML 290 165 56.9 1.02 (0.58 to 1.80)
 Hodgkin's lymphoma 200 142 71.0 2.38 (1.30 to 4.36)
 Non-Hodgkin's lymphoma 944 625 66.2 1.46 (0.92 to 2.31)
 Myeloma 378 227 60.1 0.79 (0.47 to 1.35)
Highest central temperature 0.100
 <36.0°C 127 110 86.6 2.26 (0.97 to 5.29)
 36.0 to 38.4°C 3,850 2,205 57.3 Reference
 38.5 to 40.9°C 2,900 1,714 59.1 0.94 (0.81 to 1.09)
 41.0+°C 121 80 66.1 0.70 (0.41 to 1.20)
Lowest systolic blood pressure < 0.001
 <50 mmHg 281 265 94.3 3.66 (1.93 to 6.96)
 50 to 59 mmHg 303 251 82.8 1.66 (1.09 to 2.54)
 60 to 69 mmHg 601 472 78.5 1.55 (1.15 to 2.08)
 70 to 79 mmHg 1,005 667 66.4 1.10 (0.88 to 1.37)
 80 to 99 mmHg 2,598 1,493 57.5 1.14 (0.97 to 1.34)
 100+ mmHg 2,270 1,018 44.9 Reference
Highest heart rate < 0.001
 <110 beats/min 1,895 788 41.6 Reference
 110 to 119 beats/min 1,031 553 53.6 1.32 (1.06 to 1.64)
 120 to 139 beats/min 2,119 1,326 62.6 1.57 (1.30 to 1.90)
 140+ beats/min 2,019 1,503 74.4 2.07 (1.67 to 2.55)
Highest respiratory rate, ventilated or nonventilated < 0.001
 <6 breaths/min 217 141 65.0 1.03 (0.69 to 1.53)
 6 to 11 breaths/min 1,840 893 48.5 Reference
 12 to 13 breaths/min 1,623 1,039 64.0 1.36 (1.12 to 1.65)
 14 to 24 breaths/min 2,899 1,743 60.1 1.57 (1.31 to 1.87)
 25+ breaths/min 468 344 73.5 2.81 (2.00 to 3.95)
PaO2:FiO2 < 0.001
 Ventilated
  <100 mmHg 580 386 66.6 2.78 (2.11 to 3.66)
  100 to 199 mmHg 888 446 50.2 1.34 (1.07 to 1.69)
  200+ mmHg 1,162 441 38.0 Reference
 Nonventilated
  <100 mmHg 1,220 1,033 84.7 2.71 (1.45 to 5.06)
  100 to 199 mmHg 1,374 951 69.2 1.33 (0.72 to 2.45)
  200+ mmHg 1,108 621 56.1 1.06 (0.58 to 1.95)
Lowest arterial pH < 0.001
 <7.15 1,248 1,125 90.1 2.25 (1.71 to 2.96)
 7.15 to 7.24 1,129 817 72.4 1.37 (1.11 to 1.70)
 7.25 to 7.32 1,457 797 54.7 1.09 (0.91 to 1.30)
 7.33 to 7.49 2,453 1,094 44.6 Reference
 7.50+ 93 61 65.6 2.20 (1.24 to 3.92)
Serum sodium <0.001
 <130 mmol/l 285 208 73.0 2.47 (1.70 to 3.60)
 130 to 149 mmol/l 6,125 3,486 56.9 Reference
 150 to 154 mmol/l 248 196 79.0 1.85 (1.25 to 2.73)
 155 to 159 mmol/l 72 63 87.5 3.28 (1.45 to 7.40)
 160+ mmol/l 36 28 77.8 1.34 (0.52 to 3.46)

aAnalysis of the effect of age, gender, diagnostic category, temperature, systolic blood pressure, heart rate, respiratory rate, PaO2:FiO2, arterial pH and serum sodium on outcome. ALL: acute lymphoblastic leukaemia; AML: acute myeloblastic leukaemia; CI: confidence interval; CLML: chronic lymphocytic or myeloblastic leukaemia. bOnly admissions with a haematological diagnosis as the primary, secondary or ultimate reason for admission were included in this analysis.