Table 4.
Multivariate logistic regression analysis for admissions to critical care units with haematological malignancya
| Number of admissions | Number of deaths | Percentage of deaths | Adjusted | ||
|---|---|---|---|---|---|
| Odds ratio (95% CI) | P value | ||||
| Age | < 0.001 | ||||
| <45 years | 1,512 | 831 | 55.0 | 1.14 (1.09 to 1.20) | |
| 45 to 54 years | 1,053 | 622 | 59.1 | Per 10-year increase | |
| 55 to 64 years | 1,716 | 1,006 | 58.6 | ||
| 65 to 74 years | 1,852 | 1,171 | 63.2 | ||
| 75+ years | 1,028 | 609 | 59.2 | ||
| Sex | 0.742 | ||||
| Female | 2,818 | 1,709 | 60.7 | 1.02 (0.89 to 1.18) | |
| Male | 4,343 | 2,530 | 58.3 | Reference | |
| Diagnostic categoryb | < 0.001 | ||||
| Bone marrow transplant | 143 | 93 | 65.0 | 1.88 (1.00 to 3.53) | |
| ALL | 254 | 141 | 55.5 | Reference | |
| AML | 591 | 398 | 67.3 | 1.37 (0.86 to 2.20) | |
| CLML | 290 | 165 | 56.9 | 1.02 (0.58 to 1.80) | |
| Hodgkin's lymphoma | 200 | 142 | 71.0 | 2.38 (1.30 to 4.36) | |
| Non-Hodgkin's lymphoma | 944 | 625 | 66.2 | 1.46 (0.92 to 2.31) | |
| Myeloma | 378 | 227 | 60.1 | 0.79 (0.47 to 1.35) | |
| Highest central temperature | 0.100 | ||||
| <36.0°C | 127 | 110 | 86.6 | 2.26 (0.97 to 5.29) | |
| 36.0 to 38.4°C | 3,850 | 2,205 | 57.3 | Reference | |
| 38.5 to 40.9°C | 2,900 | 1,714 | 59.1 | 0.94 (0.81 to 1.09) | |
| 41.0+°C | 121 | 80 | 66.1 | 0.70 (0.41 to 1.20) | |
| Lowest systolic blood pressure | < 0.001 | ||||
| <50 mmHg | 281 | 265 | 94.3 | 3.66 (1.93 to 6.96) | |
| 50 to 59 mmHg | 303 | 251 | 82.8 | 1.66 (1.09 to 2.54) | |
| 60 to 69 mmHg | 601 | 472 | 78.5 | 1.55 (1.15 to 2.08) | |
| 70 to 79 mmHg | 1,005 | 667 | 66.4 | 1.10 (0.88 to 1.37) | |
| 80 to 99 mmHg | 2,598 | 1,493 | 57.5 | 1.14 (0.97 to 1.34) | |
| 100+ mmHg | 2,270 | 1,018 | 44.9 | Reference | |
| Highest heart rate | < 0.001 | ||||
| <110 beats/min | 1,895 | 788 | 41.6 | Reference | |
| 110 to 119 beats/min | 1,031 | 553 | 53.6 | 1.32 (1.06 to 1.64) | |
| 120 to 139 beats/min | 2,119 | 1,326 | 62.6 | 1.57 (1.30 to 1.90) | |
| 140+ beats/min | 2,019 | 1,503 | 74.4 | 2.07 (1.67 to 2.55) | |
| Highest respiratory rate, ventilated or nonventilated | < 0.001 | ||||
| <6 breaths/min | 217 | 141 | 65.0 | 1.03 (0.69 to 1.53) | |
| 6 to 11 breaths/min | 1,840 | 893 | 48.5 | Reference | |
| 12 to 13 breaths/min | 1,623 | 1,039 | 64.0 | 1.36 (1.12 to 1.65) | |
| 14 to 24 breaths/min | 2,899 | 1,743 | 60.1 | 1.57 (1.31 to 1.87) | |
| 25+ breaths/min | 468 | 344 | 73.5 | 2.81 (2.00 to 3.95) | |
| PaO2:FiO2 | < 0.001 | ||||
| Ventilated | |||||
| <100 mmHg | 580 | 386 | 66.6 | 2.78 (2.11 to 3.66) | |
| 100 to 199 mmHg | 888 | 446 | 50.2 | 1.34 (1.07 to 1.69) | |
| 200+ mmHg | 1,162 | 441 | 38.0 | Reference | |
| Nonventilated | |||||
| <100 mmHg | 1,220 | 1,033 | 84.7 | 2.71 (1.45 to 5.06) | |
| 100 to 199 mmHg | 1,374 | 951 | 69.2 | 1.33 (0.72 to 2.45) | |
| 200+ mmHg | 1,108 | 621 | 56.1 | 1.06 (0.58 to 1.95) | |
| Lowest arterial pH | < 0.001 | ||||
| <7.15 | 1,248 | 1,125 | 90.1 | 2.25 (1.71 to 2.96) | |
| 7.15 to 7.24 | 1,129 | 817 | 72.4 | 1.37 (1.11 to 1.70) | |
| 7.25 to 7.32 | 1,457 | 797 | 54.7 | 1.09 (0.91 to 1.30) | |
| 7.33 to 7.49 | 2,453 | 1,094 | 44.6 | Reference | |
| 7.50+ | 93 | 61 | 65.6 | 2.20 (1.24 to 3.92) | |
| Serum sodium | <0.001 | ||||
| <130 mmol/l | 285 | 208 | 73.0 | 2.47 (1.70 to 3.60) | |
| 130 to 149 mmol/l | 6,125 | 3,486 | 56.9 | Reference | |
| 150 to 154 mmol/l | 248 | 196 | 79.0 | 1.85 (1.25 to 2.73) | |
| 155 to 159 mmol/l | 72 | 63 | 87.5 | 3.28 (1.45 to 7.40) | |
| 160+ mmol/l | 36 | 28 | 77.8 | 1.34 (0.52 to 3.46) | |
aAnalysis of the effect of age, gender, diagnostic category, temperature, systolic blood pressure, heart rate, respiratory rate, PaO2:FiO2, arterial pH and serum sodium on outcome. ALL: acute lymphoblastic leukaemia; AML: acute myeloblastic leukaemia; CI: confidence interval; CLML: chronic lymphocytic or myeloblastic leukaemia. bOnly admissions with a haematological diagnosis as the primary, secondary or ultimate reason for admission were included in this analysis.