Table 5.
Multivariate logistic regression analysis for admissions to critical care units with haematological malignancya
| Number of admissions | Number of deaths | Percentage of deaths | Adjusted | ||
|---|---|---|---|---|---|
| Odds ratio (95% CI) | P value | ||||
| Serum potassium | |||||
| <3.0 mmol/l | 63 | 45 | 71.4 | 2.40 (1.02 to 5.67) | 0.226 |
| 3.0 to 3.4 mmol/l | 274 | 169 | 61.7 | 1.29 (0.87 to 1.92) | |
| 3.5 to 5.4 mmol/l | 5,548 | 3,124 | 56.3 | Reference | |
| 5.5 to 5.9 mmol/l | 431 | 303 | 70.3 | 0.93 (0.69 to 1.27) | |
| 6.0 to 6.9 mmol/l | 343 | 260 | 75.8 | 1.12 (0.79 to 1.61) | |
| 7.0+ mmol/l | 106 | 83 | 78.3 | 0.79 (0.40 to 1.53) | |
| Serum urea | <0.001 | ||||
| <6.2 mmol/l | 1,315 | 504 | 38.3 | 1.05 (0.78 to 1.42) | |
| 6.2 to 7.1 mmol/l | 422 | 189 | 44.8 | Reference | |
| 7.2 to 14.3 mmol/l | 2,158 | 1,272 | 58.9 | 1.45 (1.09 to 1.93) | |
| 14.4+ mmol/l | 2,283 | 1,666 | 73.0 | 2.39 (1.74 to 3.28) | |
| Serum creatinine | 0.310 | ||||
| <0.6 μmol/l | 193 | 94 | 48.7 | 1.41 (0.94 to 2.13) | |
| 0.6 to 1.4 μmol/l | 3,104 | 1,510 | 48.7 | Reference | |
| 1.5+ μmol/l | 3,359 | 2,302 | 68.5 | 0.84 (0.70 to 1.02) | |
| Urine output | < 0.001 | ||||
| <400 ml/day | 1,121 | 956 | 85.3 | 2.91 (2.23 to 3.79) | |
| 400 to 599 ml/day | 297 | 239 | 80.5 | 2.66 (1.76 to 4.00) | |
| 600 to 899 ml/day | 488 | 341 | 69.9 | 2.05 (1.53 to 2.75) | |
| 900 to 1,499 ml/day | 1,270 | 752 | 59.2 | 1.58 (1.30 to 1.91) | |
| 1,500 to 1,999 ml/day | 984 | 515 | 52.3 | 1.37 (1.13 to 1.66) | |
| 2,000+ ml/day | 2,689 | 1,229 | 45.7 | Reference | |
| Haematocrit | 0.001 | ||||
| <20% | 171 | 119 | 69.9 | 3.22 (0.96 to 10.85) | |
| 20 to 29% | 3,073 | 1,904 | 62.0 | 4.56 (1.51 to 13.80) | |
| 30 to 45% | 3,405 | 1,897 | 55.7 | 3.69 (1.22 to 11.13) | |
| 46 to 49% | 55 | 28 | 50.9 | 2.13 (0.58 to 7.82) | |
| 50 to 59% | 26 | 10 | 38.5 | Reference | |
| 60+% | 5 | 3 | 60.0 | 1.24 (0.09 to 17.20) | |
| Lowest white blood cell count | 0.425 | ||||
| <1 × 109/l | 1,217 | 799 | 65.7 | 1.17 (00.95 to 1.45) | |
| 1 to 2 × 109/l | 820 | 503 | 61.3 | 1.15 (0.92 to 1.43) | |
| 3 to 14 × 109/l | 3,009 | 1,605 | 53.3 | Reference | |
| 15 to 39 × 109/l | 1,039 | 616 | 59.3 | 0.98 (0.80 to 1.20) | |
| 40+ × 109/l | 459 | 301 | 65.6 | 1.16 (0.86 to 1.56) | |
| Glasgow Coma Score | < 0.001 | ||||
| 3 | 511 | 437 | 85.5 | 3.32 (2.33 to 4.74) | |
| 4 | 29 | 21 | 72.4 | 1.58 (0.55 to 4.52) | |
| 5 | 30 | 22 | 73.3 | 2.20 (0.85 to 5.73) | |
| 6 | 81 | 54 | 66.7 | 1.47 (0.80 to 2.71) | |
| 7 to 13 | 595 | 392 | 65.9 | 1.80 (1.40 to 2.31) | |
| 14 | 376 | 223 | 59.3 | 1.48 (1.11 to 1.98) | |
| 15 | 3,190 | 1,385 | 43.4 | Reference | |
| Sedated | 1,518 | 1,119 | 73.7 | 1.85 (1.50 to 2.28) | |
| Sedated and paralysed | 214 | 173 | 80.8 | 2.40 (1.51 to 3.82) | |
| Mechanical ventilation | 0.154 | ||||
| No | 3,169 | 1,435 | 45.3 | Reference | |
| Yes | 3,970 | 2,788 | 70.2 | 1.53 (0.85 to 2.73) | |
| Severe sepsis | 0.001 | ||||
| No | 3,245 | 1,630 | 50.2 | Reference | |
| Yes | 3,916 | 2,609 | 66.6 | 1.29 (1.10 to 1.50) | |
| CPR within 24 hours prior to admission | 0.317 | ||||
| No | 6,728 | 3,884 | 57.7 | Reference | |
| Yes | 426 | 353 | 82.9 | 1.21 (0.84 to 1.74) | |
| Hospital length of stay before ICU admission | < 0.001 | ||||
| 0 days | 1,358 | 735 | 54.1 | 1.02 (1.01 to 1.02) | |
| 1 day | 1,266 | 614 | 48.5 | (per day) | |
| 2 to 4 days | 1,253 | 690 | 55.1 | ||
| 5 to 9 days | 977 | 617 | 63.2 | ||
| 10 to 19 days | 1,109 | 735 | 66.3 | ||
| >20 days | 1,195 | 846 | 70.8 | ||
aAnalysis of the effect of serum potassium, urea, creatinine, urine output, haematocrit, white cell count, Glasgow Coma Score, invasive ventilation, severe sepsis, cardiopulmonary resuscitation (CPR) and length of hospital stay prior to intensive care admission on outcome. CI: confidence interval; ICU: intensive care unit.