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. 2009 Jul 29;58(10):2285–2291. doi: 10.2337/db09-0091

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© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — A: Immunohistochemical demonstration of enterovirus-associated VP1 antigen in pancreatic islets (brown, arrows). Cells with shrunken and dark nuclei (arrows) suggestive of pyknosis, a sign of cell death, were observed (×400, case 1). B: Immunohistochemical staining for glucagon in serial sections of (A) (×400). Comparing (A) and (B) indicates enterovirus VP1 antigen residing on islet cells. C: Homogeneous staining for VP1 was observed in pancreatic acinar cell clusters (brown) with shrunken and darkly staining nuclei suggestive of pyknosis (arrows) (×400). (A high-quality digital representation of this figure is available in the online issue.)