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. 2009 Jul 8;58(10):2292–2302. doi: 10.2337/db09-0257

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© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — ERα protects islet survival via ERE-independent pathway. A: Cumulative incidence of diabetes (random-fed blood glucose >250 mg/dl) in wild-type, αERKO^−/−, αERKO^+/−, and αERKO^AA/− mice (n = 10–15) after STZ challenges (150 mg/kg). B: Random-fed blood glucose was measured after STZ injection (day 8). C: The ratio of random-fed insulin (pg/ml)/glucose (mg/dl) at day 8 was used as an index of insulin deficiency. Values represent the means ± SE. D: Pancreatic insulin concentration was measured after STZ injection (day 8). Values are represented as scatter plot. *P < 0.05. WT, wild type.