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. 2009 Jul 6;58(10):2396–2401. doi: 10.2337/db09-0280

FIG. 3.

FIG. 3.

Regulation of TIMP3 expression in CASMC. A: SirT1 knockdown decreased TIMP3 expression but not TIMP1, TIMP2, TIMP4, ADAM10, ADAM17, or MMP9 in CASMC. n = 4 for all experiments; ***P < 0.001 by Student's t test versus control. B: SirT1 knockdown decreased TIMP3 expression in HUVEC and THP1. n = 4 for all experiments; ***P < 0.001 by Student's t test. C: SirT1 cDNA overexpression increased Timp3 promoter activity. n = 4 for all experiments; **P < 0.01 by one-way ANOVA. D: SirT1 overexpression increased and prevented loss of TIMP3 expression caused by high glucose (HG; 20 mmol/l) in CASMC, HUVEC, and THP1. n = 4 for all experiments; *P < 0.05 by Student's t test.