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. 2009 Jul 10;58(10):2324–2334. doi: 10.2337/db09-0658

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© 2009 by the American Diabetes Association.

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FIG. 4. — Ultrastructural analyses of exact intracellular localization of the SCAs after intravenous application in a rat. Transmission electron microscopy detected the β-cell–specific SCA B1 (A and B) and the α-cell–specific SCA A1 (C and D) in the endoplasmatic reticulum (A and C) and at the secretory granule membrane (B and D) of the respective target cells exclusively (n = 4 rats per group, 20–30 sections per rat). Scale bars, 90 nm.