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. 2003 Dec 10;89(Suppl 2):S9–S14. doi: 10.1038/sj.bjc.6601477

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Copyright © 2003 Cancer Research UK

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Idealised curves reflecting molecular target effects, antitumour effects and toxicity as functions for (A) a typical cytotoxic agent whose toxicity occurs at roughly the same dose as target effects and (B) a hypothetical target-based antiproliferative agent whose target effects occur at lower doses than toxic effects. Adapted with permission from: Rowinsky EK (2000)