Table 1. Clinical response and survival in the GOG 111a and OV10b studies.
No. of patients evaluable for clinical response |
Overall response rate (%) |
Complete response rate (%) |
Median progression-free survival (months) |
Overall median survival (months) |
||||||
---|---|---|---|---|---|---|---|---|---|---|
Treatment arm | GOG 111 | OV10 | GOG 111 | OV10 | GOG 111 | OV10 | GOG 111 | OV10 | GOG 111 | OV10 |
Cisplatin+paclitaxel | 100 | 162 | 73 | 58.6* | 51* | 40.7* | 18* | 15.5* | 38* | 35.6* |
Cisplatin+cyclophosphamide | 116 | 161 | 50 | 44.7 | 31 | 27.3 | 13 | 11.5 | 24 | 25.8 |
Cisplatin 75 mg m−2+either paclitaxel 135 mg m−2 over 24 h or cyclophosphamide 750 mg m−2 every 3 weeks (McGuire et al, 1996).
Cisplatin 75 mg m−2+either paclitaxel 175 mg m−2 over 3 h or cyclophosphamide 750 mg m−2 every 3 weeks (Piccart et al, 2000).
Statistically significant difference between treatments (P<0.05).