Table 1.
Values of the constants
| Description | Symbol | Value |
|---|---|---|
| Rate of calcium leak across the plasma membrane | k0 | 0.03 μM s − 1 |
| Rate of calcium leak from the ER | k1 | 0.0004 s − 1 |
| Rate of calcium release through IP3 receptor | k2 | 0.2 s − 1 |
| Rate constant of SERCA pump | k3 | 0.5 s − 1 |
| Rate of calcium extrusion from plasma membrane | k5 | 0.5 s − 1 |
| Rate constant of IP3 receptor inactivation | k6 | 4 s − 1 |
| Rate constant of IP3 receptor degradation | k9 | 0.08 s − 1 |
| Rate constant of PLCδ | ν7 | 0.02 μM s − 1 |
| Half saturation constant for IP3 activation of the corresponding receptor | K ip 3 | 0.3 μM |
| Half saturation constant for calcium activation of the IP3 receptor | Ka | 0.2 μM |
| Half saturation constant for calcium inhibition of the IP3 receptor | Ki | 0.2 μM |
| Half saturation constant for calcium activation of PLCdelta | KCa | 0.3 μM |
| Ratio of the effective volumes for calcium of cytoplasm and ER | beta | 35 |
| Half inactivation constant for CCE influx | HCCE | 10 μM |
| Maximal rate constant for CCE influx | kCCE | 0.01 μM s − 1 |
| Maximal rate of ATP-evoked ionotropic calcium influx | kATP(P2X) | 0.08 μM s − 1 |
| Half saturation constant for ATP-evoked ionotropic calcium influx amplitude | HATP(P2X) | 0.9 μM |
| Maximal rate of IP3 production mediated by the metabotropic ATP receptor | kATP(P2Y) | 0.5 μM s − 1 |
| Dissociation constant for the binding of ATP to the P2Y receptor | KD | 10 μM |