Table 3. Multivariate analysis of survival done with exact logistic regression in the cohort of 132 patients evaluated in the study.

Molecular alteration	PFS Hazard Ratio (CI 95%)	p value	OS Hazard Ratio (CI 95%)	p value
KRAS (mutant versus wild type)	1.65 (1.041–2.601)	0.033	1.72 (1.017–2.903)	0.043
BRAF (mutant versus wild type)	1.39 (0.521–3.685)	0.513	2.31 (0.867–6.131)	0.093
PIK3CA (mutant versus wild type)	1.79 (0.801–4.017)	0.156	1.63 (0.815–3.269)	0.166
PTEN (normal versus loss)	0.77 (0.501–1.167)	0.213	0.54 (0.332–0.874)	0.012

Hazard ratio values are adjusted by score of cutaneous toxicity and number of previous chemotherapy lines.

PFS: progression-free survival; OS: overall survival.