Table 2.
Glioma | Glioblastoma* | Meningioma | |||||||
---|---|---|---|---|---|---|---|---|---|
Gene | rs# | Genotype | Controls (%)‡ | Cases (%)‡ | OR (95% CI) | Cases (%)‡ | OR (95% CI) | Cases (%)‡ | OR (95% CI) |
CAT | rs769214† | AA | 207 (45) | 152 (47) | 1 | 75 (49) | 1 | 52 (44) | 1 |
AG/GG | 250 (55) | 172 (53) | 0.9 (0.7, 1.2) | 79 (51) | 0.9 (0.6, 1.3) | 66 (56) | 1.1 (0.7, 1.7) | ||
CAT | rs1001179† | TT | 249 (57) | 186 (58) | 1 | 85 (57) | 1 | 72 (61) | 1 |
TC/CC | 186 (42) | 132 (42) | 1.0 (0.7, 1.3) | 65 (43) | 1.0 (0.7, 1.5) | 46 (39) | 0.8 (0.5, 1.2) | ||
GPX1 | rs1050450†§ | CC | 236 (52) | 158 (48) | 1 | 74 (47) | 1 | 55 (46) | 1 |
CT/TT | 221 (48) | 169 (52) | 1.1 (0.8, 1.5) | 83 (53) | 1.1 (0.8, 1.6) | 66 (55) | 1.3 (0.8, 1.9) | ||
LPO | rs8178407† | AA | 131 (40) | 92 (37) | 1 | 43 (37) | 1 | 29 (29) | 1 |
AG/GG | 196 (60) | 159 (63) | 1.2 (0.9, 1.7) | 73 (63) | 1.2 (0.7, 1.9) | 70 (70) | 1.6 (1.0, 2.7) | ||
MPO | rs4401102† | GG | 183 (56) | 137 (55) | 1 | 60 (52) | 1 | 55 (55) | 1 |
GA/AA | 144 (44) | 114 (45) | 1.0 (0.7, 1.4) | 56 (48) | 1.2 (0.8, 1.9) | 45 (45) | 1.0 (0.6, 1.7) | ||
NCF2 | rs11579965 | GG | 291 (89) | 211 (84) | 1 | 102 (88) | 1 | 79 (79) | 1 |
GC/CC | 37 (11) | 40 (16) | 1.5 (0.9, 2.5) | 14 (12) | 1.1 (0.5, 2.3) | 21 (21) | 2.0 (1.1, 3.9) | ||
NCF2 | rs11588654† | AA | 150 (46) | 125 (50) | 1 | 52 (45) | 1 | 52 (53) | 1 |
AG/GG | 178 (54) | 126 (50) | 0.8 (0.6, 1.2) | 64 (55) | 1.0 (0.6, 1.6) | 47 (47) | 0.7 (0.4, 1.2) | ||
NCF4 | rs2075938† | AA | 181 (55) | 143 (57) | 1 | 70 (60) | 1 | 54 (54) | 1 |
AG/GG | 146 (45) | 108 (43) | 1.0 (0.7, 1.4) | 46 (40) | 0.8 (0.5, 1.3) | 46 (46) | 1.1 (0.7, 1.8) | ||
NCF4 | rs5756381† | AA | 185 (56) | 147 (59) | 1 | 70 (60) | 1 | 55 (55) | 1 |
AG/GG | 143 (44) | 104 (41) | 0.9 (0.7, 1.3) | 46 (40) | 0.8 (0.5, 1.3) | 45 (45) | 1.1 (0.7, 1.8) | ||
NCF4 | rs8137602† | CC | 261 (80) | 216 (86) | 1 | 101 (87) | 1 | 87 (87) | 1 |
CG/GG | 67 (20) | 35 (14) | 0.6 (0.4, 1.0) | 15 (13) | 0.5 (0.3, 1.0) | 13 (13) | 0.6 (0.3, 1.2) | ||
NOS1 | rs483589† | CC | 119 (37) | 96 (38) | 1 | 48 (41) | 1 | 37 (37) | 1 |
CT/TT | 207 (64) | 155 (62) | 1.0 (0.7, 1.3) | 68 (59) | 0.9 (0.6, 1.5) | 63 (63) | 1.0 (0.6, 1.6) | ||
NOS1 | rs545654† | GG | 92 (28) | 56 (22) | 1 | 29 (25) | 1 | 27 (27) | 1 |
GA/AA | 235 (72) | 195 (78) | 1.3 (0.9, 2.0) | 87 (75) | 1.1 (0.7, 1.9) | 73 (73) | 1.0 (0.6, 1.7) | ||
NOS1 | rs816293† | GG | 109 (33) | 93 (38) | 1 | 47 (41) | 1 | 40 (40) | 1 |
GC/CC | 218 (67) | 155 (63) | 0.9 (0.6, 1.2) | 69 (59) | 0.9 (0.5, 1.4) | 60 (60) | 0.7 (0.4, 1.1) | ||
NOS1 | rs816351 | TT | 269 (82) | 219 (87) | 1 | 104 (90) | 1 | 78 (79) | 1 |
TC/CC | 59 (18) | 32 (13) | 0.6 (0.4, 1.0) | 12 (10) | 0.5 (0.3, 1.0) | 21 (21) | 1.4 (0.8, 2.6) | ||
NOS1 | rs1123425† | TT | 114 (35) | 76 (30) | 1 | 42 (36) | 1 | 24 (24) | 1 |
TC/CC | 212 (65) | 175 (70) | 1.2 (0.8, 1.7) | 74 (64) | 0.8 (0.5, 1.3) | 76 (76) | 1.7 (1.0, 3.0) | ||
NOS1 | rs1353939† | GG | 206 (63) | 154 (61) | 1 | 68 (59) | 1 | 61 (61) | 1 |
GA/AA | 121 (37) | 97 (39) | 1.1 (0.8, 1.5) | 48 (41) | 1.2 (0.8, 1.9) | 39 (39) | 1.2 (0.7, 2.0) | ||
NOS1 | rs2291908† | AA | 162 (50) | 112 (45) | 1 | 49 (42) | 1 | 44 (44) | 1 |
AG/GG | 164 (50) | 139 (55) | 1.3 (0.9, 1.7) | 67 (58) | 1.4 (0.9, 2.2) | 56 (56) | 1.4 (0.8, 2.2) | ||
NOS1 | rs4767535† | GG | 94 (29) | 65 (26) | 1 | 29 (25) | 1 | 26 (26) | 1 |
GA/AA | 233 (71) | 186 (74) | 1.1 (0.8, 1.6) | 87 (75) | 1.0 (0.6, 1.8) | 74 (74) | 1.1 (0.6, 1.9) | ||
NOS1 | rs6490121† | CC | 147 (45) | 104 (42) | 1 | 50 (43) | 1 | 41 (41) | 1 |
CT/TT | 181 (55) | 146 (58) | 1.1 (0.8, 1.6) | 66 (57) | 1.1 (0.7, 1.7) | 59 (59) | 1.2 (0.7, 1.9) | ||
NOS1 | rs7298903† | AA | 271 (83) | 206 (82) | 1 | 97 (84) | 1 | 82 (83) | 1 |
AG/GG | 55 (17) | 44 (18) | 1.0 (0.7, 1.6) | 19 (16) | 0.9 (0.5, 1.7) | 17 (17) | 1.2 (0.6, 2.3) | ||
NOS1 | rs10850803 | TT | 272 (83) | 198 (79) | 1 | 91 (78) | 1 | 72 (72) | 1 |
TC/CC | 54 (17) | 52 (21) | 1.3 (0.9, 2.0) | 25 (22) | 1.4 (0.8, 2.5) | 28 (28) | 2.0 (1.1, 3.6) | ||
NOS2A | rs944725† | GG | 117 (36) | 92 (37) | 1 | 42 (36) | 1 | 40 (40) | 1 |
GA/AA | 211 (64) | 159 (63) | 1.0 (0.7, 1.4) | 74 (64) | 0.8 (0.5, 1.3) | 60 (60) | 0.7 (0.4, 1.2) | ||
NOS2A | rs2297516† | TT | 119 (37) | 99 (39) | 1 | 46 (40) | 1 | 37 (37) | 1 |
TG/GG | 207 (64) | 152 (61) | 0.9 (0.7, 1.3) | 70 (60) | 0.9 (0.6, 1.4) | 63 (63) | 1.0 (0.6, 1.6) | ||
NOS2A | rs2779252† | CC | 298 (91) | 231 (92) | 1 | 109 (94) | 1 | 91 (91) | 1 |
CA/AA | 29 (9) | 20 (8) | 0.8 (0.5, 1.5) | 7 (6) | 0.6 (0.3, 1.6) | 9 (9) | 1.2 (0.5, 2.7) | ||
NOS2A | rs4795067† | TT | 141 (43) | 104 (41) | 1 | 55 (47) | 1 | 38 (38) | 1 |
TC/CC | 187 (57) | 147 (59) | 1.0 (0.7, 1.5) | 61 (53) | 0.8 (0.5, 1.3) | 62 (62) | 1.1 (0.7, 1.9) | ||
NOS2A | rs8072199 | GG | 124 (38) | 79 (31) | 1 | 40 (34) | 1 | 28 (28) | 1 |
GA/AA | 203 (62) | 172 (69) | 1.3 (0.9, 1.8) | 76 (66) | 1.0 (0.6, 1.6) | 71 (72) | 1.7 (1.0, 3.0) | ||
NOS3 | rs1799983† | TT | 203 (44) | 150 (46) | 1 | 73 (47) | 1 | 52 (43) | 1 |
TG/GG | 261 (56) | 176 (54) | 0.9 (0.7, 1.2) | 84 (54) | 1.0 (0.6, 1.4) | 69 (57) | 0.9 (0.6, 1.4) | ||
NOS3 | rs4496877† | GG | 107 (33) | 88 (35) | 1 | 35 (30) | 1 | 39 (39) | 1 |
GT/TT | 219 (67) | 163 (65) | 0.9 (0.6, 1.3) | 81 (70) | 1.1 (0.7, 1.8) | 61 (61) | 0.7 (0.4, 1.1) | ||
NOS3 | rs12703107† | GG | 188 (57) | 136 (54) | 1 | 66 57) | 1 | 51 (52) | 1 |
GT/TT | 140 (43) | 115 (46) | 1.1 (0.8, 1.6) | 50 (43) | 1.1 (0.7, 1.8) | 48 (48) | 1.3 (0.8, 2.1) | ||
RAC1 | rs836554† | CC | 193 (59) | 146 (58) | 1 | 68 (59) | 1 | 52 (52) | 1 |
CT/TT | 134 (41) | 105 (42) | 1.1 (0.8, 1.5) | 48 (41) | 0.9 (0.6, 1.5) | 48 (48) | 1.3 (0.8, 2.2) | ||
RAC1 | rs6463554† | GG | 235 (72) | 198 (79) | 1 | 95 (82) | 1 | 69 (69) | 1 |
GC/CC | 93 (28) | 53 (21) | 0.7 (0.5, 1.0) | 21 (18) | 0.5 (0.3, 0.9) | 31 (31) | 1.1 (0.7, 1.9) | ||
RAC1 | rs3729790† | GG | 193 (59) | 148 (59) | 1 | 68 (59) | 1 | 64 (64) | 1 |
GA/AA | 135 (41) | 103 (41) | 1.0 (0.7, 1.5) | 48 (41) | 1.1 (0.7, 1.8) | 36 (36) | 0.7 (0.5, 1.2) | ||
RAC2 | rs6572† | GG | 108 (33) | 80 (32) | 1 | 37 (32) | 1 | 26 (26) | 1 |
GC/CC | 220 (67) | 171 (68) | 1.0 (0.7, 1.5) | 79 (68) | 1.2 (0.7, 1.9) | 74 (74) | 1.4 (0.8, 2.4) | ||
RAC2 | rs1476002† | AA | 248 (76) | 191 (76) | 1 | 90 (78) | 1 | 68 (68) | 1 |
AG/GG | 79 (24) | 60 (24) | 1.0 (0.7, 1.4) | 26 (22) | 0.8 (0.5, 1.4) | 32 (32) | 1.6 (0.9, 2.7) | ||
RAC2 | rs2213430 | AA | 102 (31) | 69 (27) | 1 | 30 (26) | 1 | 37 (27) | 1 |
AG/GG | 226 (69) | 182 (73) | 1.3 (0.9, 1.8) | 86 (74) | 1.2 (0.7, 2.0) | 63 (63) | 0.5 (0.3, 0.8) | ||
RAC2 | rs2239774† | CC | 239 (73) | 186 (74) | 1 | 89 (77) | 1 | 73 (73) | 1 |
CG/GG | 89 (27) | 65 (26) | 0.9 (0.6, 1.4) | 27 (23) | 0.9 (0.6, 1.6) | 27 (27) | 1.2 (0.7, 2.1) | ||
RAC2 | rs2239775† | GG | 240 (73) | 202 (80) | 1 | 88 (76) | 1 | 66 (66) | 1 |
GT/TT | 87 (27) | 49 (20) | 0.6 (0.4, 0.9) | 28 (24) | 0.8 (0.5, 1.3) | 34 (34) | 1.8 (1.1, 3.1) | ||
RAC2 | rs4820274† | GG | 252 (77) | 185 (74) | 1 | 87 (75) | 1 | 67 (67) | 1 |
GC/CC | 75 (23) | 66 (26) | 1.2 (0.8, 1.8) | 29 (25) | 1.3 (0.8, 2.2) | 33 (33) | 1.9 (1.1, 3.3) | ||
RAC2 | rs4821609† | TT | 161 (49) | 132 (53) | 1 | 61 (53) | 1 | 48 (48) | 1 |
TC/CC | 165 (51) | 119 (47) | 0.9 (0.6, 1.2) | 55 (47) | 0.9 (0.6, 1.4) | 52 (52) | 1.1 (0.6, 1.8) | ||
RAC2 | rs9607432† | AA | 267 (82) | 199 (79) | 1 | 94 (81) | 1 | 75 (75) | 1 |
AG/GG | 60 (18) | 52 (21) | 1.2 (0.8, 1.8) | 22 (19) | 1.3 (0.7, 2.4) | 25 (25) | 1.9 (1.0, 3.4) | ||
SOD1 | rs202445† | TT | 209 (64) | 165 (65) | 1 | 72 (62) | 1 | 72 (72) | 1 |
TC/CC | 117 (36) | 86 (34) | 0.9 (0.6, 1.3) | 44 (38) | 0.9 (0.6, 1.5) | 28 (28) | 0.7 (0.4, 1.2) | ||
SOD2 | rs4880† | TT | 121 (27) | 79 (25) | 1 | 37 (24) | 1 | 39 (33) | 1 |
TC/CC | 327 (73) | 240 (75) | 1.1 (0.8, 1.6) | 117 (76) | 1.1 (0.7, 1.8) | 80 (67) | 0.8 (0.5, 1.2) | ||
SOD2 | rs2758352 | TT | 194 (59) | 156 (62) | 1 | 78 (67) | 1 | 54 (54) | 1 |
TC/CC | 133 (41) | 94 (38) | 0.9 (0.6, 1.3) | 38 (33) | 0.6 (0.4, 1.0) | 46 (46) | 1.1 (0.7, 1.8) | ||
SOD2 | rs5746136† | GG | 163 (50) | 119 (47) | 1 | 49 (42) | 1 | 44 (44) | 1 |
GA/AA | 164 (50) | 132 (53) | 1.1 (0.8, 1.5) | 67 (58) | 1.4 (0.9, 2.3) | 56 (56) | 1.4 (0.9, 2.2) | ||
SOD2 | rs5746151† | GG | 289 (88) | 219 (87) | 1 | 100 (86) | 1 | 83 (83) | 1 |
AG/AA | 39 (12) | 32 (13) | 1.1 (0.7, 1.8) | 16 (14) | 1.6 (0.8, 3.2) | 17 (17) | 1.9 (0.9, 3.9) | ||
SOD3 | rs699473†§ | CC | 208 (45) | 125 (39) | 1 | 66 (42) | 1 | 41 (34) | 1 |
CT/TT | 251 (55) | 199 (61) | 1.3 (1.0, 1.8) | 90 (58) | 1.1 (0.8, 1.7) | 80 (66) | 1.7 (1.1, 2.6) | ||
XDH | rs206849 | TT | 102 (31) | 99 (39) | 1 | 49 (42) | 1 | 38 (38) | 1 |
TC/CC | 224 (69) | 152 (61) | 0.7 (0.5, 1.0) | 67 (58) | 0.6 (0.4, 1.0) | 62 (62) | 0.9 (0.6, 1.5) | ||
XDH | rs207444 | TT | 290 (89) | 226 (90) | 1 | 103 (89) | 1 | 96 (96) | 1 |
TC/CC | 37 (11) | 25 (10) | 0.9 (0.5, 1.6) | 13 (11) | 1.0 (0.5, 2.0) | 4 (4) | 0.3 (0.09, 0.8) | ||
XDH | rs494852 | GG | 235 (72) | 157 (63) | 1 | 71 (61) | 1 | 62 (62) | 1 |
GA/AA | 92 (28) | 94 (37) | 1.5 (1.1, 2.2) | 45 (39) | 1.6 (1.0, 2.7) | 38 (38) | 1.4 (0.9, 2.4) | ||
XDH | rs1429376† | TT | 175 (53) | 133 (53) | 1 | 61 (53) | 1 | 51 (51) | 1 |
TG/GG | 152 (46) | 118 (47) | 1.0 (0.7, 1.4) | 55 (47) | 1.0 (0.6, 1.6) | 49 (49) | 1.0 (0.6, 1.6) | ||
XDH | rs7574920† | CC | 77 (24) | 63 (25) | 1 | 21 (18) | 1 | 20 (20) | 1 |
CG/GG | 250 (76) | 187 (75) | 0.9 (0.6, 1.3) | 95 (82) | 1.4 (0.8, 2.5) | 80 (80) | 1.2 (0.6, 2.1) | ||
XDH | rs6718606† | GG | 221 (67) | 157 (63) | 1 | 66 (57) | 1 | 66 (66) | 1 |
GC/CC | 107 (33) | 94 (37) | 1.3 (0.9, 1.8) | 50 (43) | 1.8 (1.1, 2.8) | 34 (34) | 1.0 (0.6, 1.7) | ||
XDH | rs17038412† | AA | 222 (68) | 174 (69) | 1 | 77 (66) | 1 | 66 (66) | 1 |
AT/TT | 106 (32) | 77 (31) | 0.9 (0.6, 1.3) | 39 (34) | 1.0 (0.6, 1.6) | 34 (34) | 1.1 (0.6, 1.8) |
Cases with glioblastoma are a subset of the cases with glioma
See Table 3 for effect modification results with cumulative lead exposure
Same group of controls used for each tumor type; Final numbers consist of individuals with non-missing data for cumulative lead exposure that were successfully genotyped
GPX1 rs1050450 is highly correlated with rs1800668 (r2 = 0.9); SOD3 rs699473 is highly correlated with rs2284659 (r2 = 0.9)